The visions of Jesus and Mary reported by Blessed Anne Catherine Emmerich, and written by Klemens Brentano in 1852, led a French priest Abbé Julien Gouyet to discover a house near Ephesus in Turkey in 1881. This house is assumed by some Catholics and some Muslims to be the House of the Virgin Mary. The Holy See has taken no official position on the authenticity of the discovery yet, but in 1896 Pope Leo XIII visited it and in 1951 Pope Pius XII initially declared the house a Holy Place. Pope John XXIII later made the declaration permanent. Pope Paul VI in 1967, Pope John Paul II in 1979 and Pope Benedict XVI in 2006 visited the house and treated it as a shrine.

A great many traditions revolve around the Ever-Virgin Mary, the Theotokos, in Orthodoxy. It is believed by Orthodox Christians that she was and remained a Virgin before and after Christ's birth. Many of the Church's beliefs concerning the Virgin Mary are reflected in the apocryphal text "The Nativity of Mary", which was not included in scripture, but is considered by Orthodox faithful to be accurate in its description of events. This tells that the child Mary was consecrated at the age of three to serve in the temple as a temple virgin. Zachariah, at that time High Priest of the Temple, did the unthinkable and carried Mary into the Holy of Holies as a sign of her importance – that she herself would become the ark in which God would take form. At the age of twelve she was required to give up her position and marry, but she desired to remain forever a virgin in dedication to God. And so it was decided to marry her to a close relative, Joseph, an uncle or cousin, an older man, a widower, who would take care of her and allow her to retain her virginity. And so it was that when the time came she submitted to God's will and allowed the Christ to take form within her. It is believed by many Orthodox that she, in her life, committed no sin; however, the Orthodox do not accept the Roman Catholic doctrine of the Immaculate conception. In the theology of the Orthodox Church, Christ was, from the very moment of conception, was fully God and fully man. Therefore Orthodox Christians believe that it is correct to say that Mary is indeed the Theotokos, the Birth-giver of God, and that she is the greatest of all humans ever to have lived except for Christ her Son.

After the birth of Jesus the Orthodox Church believes that she remained a virgin, continuing to serve God in all ways. She traveled much with her son, and was present both at his Passion on the Cross and at his ascension into heaven. It is also believed that she was the first to know of her son's resurrection – the Archangel Gabriel appearing to her once more and revealing it to her. It is believed she lived to the age of seventy and called all the apostles to her before she died. According to tradition Saint Thomas arrived late and was not present at her death. Desiring to kiss her hand one last time he opened her tomb but her body was gone. The Orthodox believe she was assumed into heaven bodily; however, unlike in the Roman Catholic Church, it is not a dogmatic prescription, and the holy day is usually referred to as the Feast of the Dormition, rather than the Assumption.